Misa has battled severe PMS throughout her adult life, making it challenging for her to function at work and in social situations. As a result, she often sacrifices parts of her life. One day, in a moment of frustration, she lashes out at Takatoshi, a new colleague who struggles with frequent anxiety attacks. Their personal challenges create a bond between them, and together they begin to find ways to cope. While the premise may seem heavy, Shô Miyake's direction brings a compassionate and gentle tone to the film. "All the Long Nights is steadfast in its refusal to villanize anyone or anything, except that stubborn little voice that lives inside your head and delights in insisting you’re not good enough" (Variety).